GRM4

Across TCGA cell cohorts, GRM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,632 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible GRM4-associated GO terms across cancer lineages are Establishment of protein localization to organelle, Primary alcohol biosynthetic process, and Aldosterone biosynthetic process. Each is linked with GRM4 in more than 6 cancer types. Because this analysis shows association rather than direction, both GRM4-to-partner and partner-to-GRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to organelle grouped by GRM4-low versus GRM4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM4→partner) and Y-score (partner→GRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.057	+0.175	<.001	.002	3	6
OESOPHAGUS	Primary alcohol biosynthetic process →	-0.277	-0.653	<.001	.002	3	6
BREAST	Aldosterone biosynthetic process →	+1.172	+1.069	<.001	.008	3	6
LUNG_NSCLC_LUSC	Positive regulation of DNA metabolic process →	+0.039	+0.293	.005	.004	2	7
LUNG_SCLC	Regulation of myoblast fusion →	+0.100	+1.977	.002	<.001	2	7
LUNG_SCLC	Cytoplasmic translation →	+0.078	+1.694	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,632 associations by consensus.

Establishment of protein localization to organelle by GRM4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →