GRM4

Across TCGA cell cohorts, GRM4 mutation is significantly associated with the RNA expression of many other genes, with 369 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRM4-associated genes across cancer lineages are ELOVL4, FUT5, and TSHB. Each is linked with GRM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRM4-to-partner and partner-to-GRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOVL4 grouped by GRM4-low versus GRM4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM4→partner) and Y-score (partner→GRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ELOVL4 →	+2.070	+3.614	<.001	.002	2	3
BLOOD_Leukemia	FUT5 →	+0.170	+3.359	<.001	<.001	3	2
BLOOD_Leukemia	TSHB →	+0.133	+2.954	<.001	<.001	3	2
BLOOD_Leukemia	UCN →	+0.572	+3.115	.001	.009	3	2
BLOOD_Leukemia	GSG1L →	+0.231	+2.531	.001	.004	3	2
BLOOD_Leukemia	TBC1D28 →	+0.061	+3.019	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 369 associations by consensus.

ELOVL4 by GRM4 expression — BLOOD_Leukemia

Explore this box plot interactively →