Across TCGA patient cohorts, GRM3 mutation is significantly associated with the RNA expression of many other genes, with 4,732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM3-associated genes across cancer lineages are GNPNAT1, BCCIP, and TSR1. Each is linked with GRM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRM3-to-partner and partner-to-GRM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM3→partner) and Y-score (partner→GRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPNAT1 →	+0.452	+1.285	<.001	.003	3	5
HNSC	BCCIP →	+0.368	+3.494	<.001	.002	3	5
COAD	TSR1 →	+0.424	+2.625	<.001	<.001	3	5
UCEC	SCNN1B →	-1.174	-2.754	<.001	<.001	3	5
UCEC	BUB3 →	+0.301	+1.439	<.001	.002	3	5
STAD	PBK →	+0.974	+3.186	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,732 associations by consensus.

Exploration

GRM3 survival (RNA) · tumor vs normal (RNA) · all GRM3 data types