Across TCGA patient cohorts, GRM3 mutation is significantly associated with the total protein of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRM3-associated genes across cancer lineages are Cyclin-B1, MAPK_pT202_Y204, and eIF4E. Each is linked with GRM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRM3-to-partner and partner-to-GRM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM3→partner) and Y-score (partner→GRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.464	+2.247	.001	.001	3	5
LUSC	MAPK_pT202_Y204 →	-0.311	-3.000	.039	.035	3	4
UCEC	eIF4E →	+0.139	+1.530	.009	.003	3	4
UCEC	4E-BP1 →	+0.253	+1.440	<.001	<.001	3	4
STAD	FASN →	+0.319	+3.185	.035	.009	3	3
COAD	Caspase-7-cleavedD198 →	+0.808	+3.459	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

Exploration

GRM3 survival (RNA) · tumor vs normal (RNA) · all GRM3 data types