Across TCGA cell cohorts, GRM3 mutation is significantly associated with the RNA expression of many other genes, with 965 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRM3-associated genes across cancer lineages are IL36A, ZNF683, and KIAA1210. Each is linked with GRM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRM3-to-partner and partner-to-GRM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM3→partner) and Y-score (partner→GRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL36A →	+0.016	+4.058	<.001	.007	3	3
CNS	ZNF683 →	+0.031	+3.643	<.001	.001	3	2
CNS	KIAA1210 →	+0.100	+3.196	<.001	.004	3	2
LARGE_INTESTINE	METTL16 →	+0.507	+2.743	.002	.001	3	2
LARGE_INTESTINE	GABRE →	-1.769	-2.657	<.001	.002	3	2
LARGE_INTESTINE	BAG2 →	+0.897	+3.321	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 965 associations by consensus.

Exploration

GRM3 survival (RNA) · tumor vs normal (RNA) · all GRM3 data types