GRM2

Across TCGA patient cohorts, GRM2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GRM2-associated genes across cancer lineages are Cyclin-B1, PCNA, and FASN. Each is linked with GRM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRM2-to-partner and partner-to-GRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by GRM2-low versus GRM2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM2→partner) and Y-score (partner→GRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.711	+3.182	<.001	.009	3	4
SKCM	PCNA →	+0.234	+3.000	.019	.035	3	3
STAD	FASN →	+0.455	+2.337	.005	.018	3	2
STAD	Rab11 →	-0.147	-3.169	.029	.017	3	2
STAD	Tuberin_pT1462 →	-0.157	-2.321	.039	.032	3	2
COAD	eIF4E →	+0.237	+2.334	.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Cyclin-B1 by GRM2 expression — SKCM

Explore this box plot interactively →