GRM2

Across TCGA cell cohorts, GRM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,828 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GRM2-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Regulation of double-strand break repair, and Positive regulation of DNA repair. Each is linked with GRM2 in more than 12 cancer types. Because this analysis shows association rather than direction, both GRM2-to-partner and partner-to-GRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by GRM2-low versus GRM2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM2→partner) and Y-score (partner→GRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.082	+2.383	<.001	.002	3	13
LUNG_SCLC	Regulation of double-strand break repair →	+0.078	+2.183	<.001	<.001	3	12
BONE	Positive regulation of DNA repair →	+0.069	+2.195	<.001	<.001	3	12
LUNG_SCLC	Heterochromatin formation →	+0.071	+1.788	<.001	<.001	3	11
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.065	+1.917	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of RNA splicing →	+0.059	+0.152	.001	.003	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,828 associations by consensus.

Positive regulation of double-strand break repair by GRM2 expression — BONE

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