GRM2

Across TCGA cell cohorts, GRM2 mutation is significantly associated with the RNA expression of many other genes, with 1,353 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRM2-associated genes across cancer lineages are GIMD1, GNG14, and CROCC. Each is linked with GRM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRM2-to-partner and partner-to-GRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMD1 grouped by GRM2-low versus GRM2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRM2→partner) and Y-score (partner→GRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GIMD1 →	+0.021	+4.152	.004	.009	3	2
SKIN	GNG14 →	+0.198	+3.544	.004	.006	3	2
LARGE_INTESTINE	CROCC →	+1.002	+3.321	.002	.003	3	2
BLOOD_Leukemia	TEX26 →	+0.023	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	AMY1A →	+0.083	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,353 associations by consensus.

GIMD1 by GRM2 expression — BLOOD_Leukemia

Explore this box plot interactively →