GRM1

Across TCGA pan-cancer cohorts, GRM1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GRM1 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GRM1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GRM1 expression acts as an unfavorable survival marker.

COAD, UCEC, and MESO are the cancer types where GRM1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	IV	0.082	0.659	<.001	12	view →
UCEC	OS	Median	IV	0.259	0.770	<.001	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
PRAD	DFS	Median	All	0.808	0.935	.003	6	view →
STAD	OS	Median	IV	0.001	0.544	<.001	6	view →
LUAD	OS	Median	III,IV	0.158	0.660	.019	6	view →
HNSC	OS	Median	All	0.474	0.694	.026	4	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GRM1–COAD (OS)

Open the COAD breakdown →