GRK7

Across TCGA pan-cancer cohorts, GRK7 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GRK7 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GRK7 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GRK7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BRCA, and HNSC are the cancer types where GRK7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.938	0.302	.008	22	view →
BRCA	OS	Median	III,IV	0.146	0.833	<.001	20	view →
HNSC	OS	Median	All	0.169	0.710	.008	18	view →
LUSC	OS	Median	II,III,IV	0.134	0.420	.020	9	view →
SKCM	DFS	Median	III,IV	0.046	0.648	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GRK7–UCEC (DFS)

Open the UCEC breakdown →