GRK7

Across TCGA patient cohorts, GRK7 mutation is significantly associated with the RNA expression of many other genes, with 3,610 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRK7-associated genes across cancer lineages are COPS3, KIF2C, and CDCA2. Each is linked with GRK7 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRK7-to-partner and partner-to-GRK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS3 grouped by GRK7-low versus GRK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK7→partner) and Y-score (partner→GRK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS3 →	+0.551	+2.949	<.001	<.001	3	4
UCEC	KIF2C →	+0.796	+3.828	<.001	<.001	3	4
UCEC	CDCA2 →	+0.865	+2.523	<.001	<.001	3	4
SKCM	NOC2L →	+0.391	+2.254	.005	.001	3	4
LIHC	ATP5MFP1 →	+0.192	+5.544	<.001	.004	3	3
UCEC	GUF1 →	+0.485	+2.526	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,610 associations by consensus.

COPS3 by GRK7 expression — UCEC

Explore this box plot interactively →