GRK7

Across TCGA patient cohorts, GRK7 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRK7-associated genes across cancer lineages are FoxM1, Stathmin, and INPP4B. Each is linked with GRK7 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRK7-to-partner and partner-to-GRK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GRK7-low versus GRK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK7→partner) and Y-score (partner→GRK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.274	+2.247	.003	.001	3	4
UCEC	Stathmin →	+0.177	+2.247	<.001	.001	3	3
UCEC	INPP4B →	-0.296	-3.700	.012	.001	3	2
UCEC	mTOR_pS2448 →	-0.150	-2.102	.006	.016	3	2
UCEC	Notch1 →	+0.168	+2.710	.001	.003	3	2
UCEC	PCNA →	+0.281	+2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FoxM1 by GRK7 expression — UCEC

Explore this box plot interactively →