GRK7

Across TCGA cell cohorts, GRK7 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,170 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRK7-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Nucleic acid catabolic process, and Negative regulation of myoblast fusion. Each is linked with GRK7 in more than 11 cancer types. Because this analysis shows association rather than direction, both GRK7-to-partner and partner-to-GRK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by GRK7-low versus GRK7-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK7→partner) and Y-score (partner→GRK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.084	+0.091	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.047	+0.138	.001	.009	3	10
STOMACH	Negative regulation of myoblast fusion →	+0.096	+0.021	<.001	.007	2	11
STOMACH	Regulation of translational initiation →	+0.061	+0.022	<.001	.005	3	9
STOMACH	Regulation of stem cell population maintenance →	+0.108	+0.041	.003	<.001	3	9
LARGE_INTESTINE	Negative regulation of mRNA splicing, via spliceosome →	+0.104	+0.097	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,170 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by GRK7 expression — LARGE_INTESTINE

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