GRK7

Across TCGA cell cohorts, GRK7 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GRK7-associated genes across cancer lineages are ZSCAN1, TBL1Y, and ADRA1A. Each is linked with GRK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK7-to-partner and partner-to-GRK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSCAN1 grouped by GRK7-low versus GRK7-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK7→partner) and Y-score (partner→GRK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
LUNG_NSCLC_LUAD	ADRA1A →	+0.050	+3.980	.003	.002	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.022	+3.887	<.001	.002	3	1
LUNG_NSCLC_LUAD	ASZ1 →	+0.446	+4.157	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR2L13 →	+0.024	+3.628	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ZSCAN1 by GRK7 expression — PANCREAS

Explore this box plot interactively →