Across TCGA pan-cancer cohorts, GRK6 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GRK6 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher GRK6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GRK6 expression acts as an unfavorable survival marker.

ESCA and UCEC are the cancer types where GRK6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.108	0.687	<.001	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: GRK6 tumor-vs-normal RNA expression · all GRK6 data types