Across TCGA pan-cancer cohorts, GRK6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GRK6 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GRK6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GRK6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where GRK6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.791	0.442	.004	20	view →
PDAC	OS	Quartile	III,IV	0.259	0.951	.008	17	view →
CCRCC	DFS	Median	All	0.528	0.900	.009	12	view →
LSCC	DFS	Quartile	All	0.815	0.369	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: GRK6 tumor-vs-normal RNA expression · all GRK6 data types