Across TCGA patient cohorts, GRK6 protein abundance is significantly associated with the protein abundance of many other proteins, with 22,585 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GRK6-associated proteins across cancer lineages are DEF6, NCF1, and PRKCB. Each is linked with GRK6 in more than 9 cancer types. Because this analysis shows association rather than direction, both GRK6-to-partner and partner-to-GRK6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK6→partner) and Y-score (partner→GRK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DEF6 →	+0.465	+0.459	<.001	<.001	3	10
LSCC	NCF1 →	+0.721	+0.465	<.001	<.001	3	10
LSCC	PRKCB →	+0.755	+0.495	<.001	<.001	3	10
LSCC	CORO1A →	+0.823	+0.504	<.001	<.001	3	9
BRCA	CYBB →	+0.897	+0.447	<.001	<.001	3	9
LSCC	FMNL1 →	+0.689	+0.492	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,585 associations by consensus.

Exploration

GRK6 survival (RNA) · tumor vs normal (RNA) · all GRK6 data types