Across TCGA cell cohorts, GRK6 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRK6-associated genes across cancer lineages are MYOD1, TKTL2, and ASCL3. Each is linked with GRK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK6-to-partner and partner-to-GRK6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK6→partner) and Y-score (partner→GRK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYOD1 →	+0.009	+2.777	.001	.004	3	1
LARGE_INTESTINE	TKTL2 →	+0.042	+3.657	<.001	.001	3	1
LARGE_INTESTINE	ASCL3 →	+0.116	+2.989	.007	.003	3	1
LARGE_INTESTINE	OR52H1 →	+0.016	+2.669	.003	.004	3	1
LARGE_INTESTINE	ACTL7A →	+0.016	+2.938	.008	.003	3	1
LARGE_INTESTINE	PPP3R2 →	+0.032	+2.621	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

GRK6 survival (RNA) · tumor vs normal (RNA) · all GRK6 data types