Across TCGA cell cohorts, GRK6 mutation is significantly associated with the mutation status of many other genes, with 3,112 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRK6-associated genes across cancer lineages are CDHR2, BMPR2, and PCDHA4. Each is linked with GRK6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRK6-to-partner and partner-to-GRK6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK6→partner) and Y-score (partner→GRK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CDHR2 →	+4.297	+4.857	.009	.009	1	3
LARGE_INTESTINE	BMPR2 →	+1.532	+2.406	.007	.007	1	3
BLOOD_Leukemia	PCDHA4 →	+2.465	+3.156	.005	.005	1	3
BREAST	CLIP2 →	+5.297	+5.297	.004	.004	1	3
BREAST	TRIM3 →	+5.297	+5.297	.004	.004	1	3
BREAST	ITGA4 →	+5.297	+5.297	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,112 associations by consensus.

Exploration

GRK6 survival (RNA) · tumor vs normal (RNA) · all GRK6 data types