GRK2

Across TCGA pan-cancer cohorts, GRK2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GRK2 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GRK2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRK2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

COAD, HNSC, and LUAD are the cancer types where GRK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.871	1.000	.011	36	view →
HNSC	DFS	Median	IV	0.784	0.573	.024	10	view →
LUAD	OS	Quartile	III,IV	0.317	0.842	.005	10	view →
PDAC	OS	Quartile	All	0.668	0.966	.014	4	view →
LSCC	DFS	Median	All	0.929	0.615	.025	1	view →
CCRCC	DFS	Tertile	II,III,IV	0.739	0.441	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GRK2–COAD (DFS)

Open the COAD breakdown →