GRK2

Across TCGA patient cohorts, GRK2 mutation is significantly associated with the RNA expression of many other genes, with 1,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRK2-associated genes across cancer lineages are IPO7P1, DCAF4L1, and BICD2. Each is linked with GRK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRK2-to-partner and partner-to-GRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IPO7P1 grouped by GRK2-low versus GRK2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK2→partner) and Y-score (partner→GRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IPO7P1 →	+0.164	+3.048	<.001	<.001	3	3
UCEC	DCAF4L1 →	+0.240	+2.163	<.001	.009	3	2
UCEC	BICD2 →	+0.551	+2.606	<.001	.005	3	2
UCEC	EMID1 →	-1.203	-2.692	.002	.006	3	2
UCEC	CENPP →	+0.309	+3.459	<.001	.005	3	2
UCEC	SPOUT1 →	+0.336	+3.595	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,015 associations by consensus.

IPO7P1 by GRK2 expression — SKCM

Explore this box plot interactively →