GRK2

Across TCGA patient cohorts, GRK2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRK2-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and STAT3_pY705. Each is linked with GRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK2-to-partner and partner-to-GRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GRK2-low versus GRK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK2→partner) and Y-score (partner→GRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.195	+2.584	.047	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.884	+3.189	.001	.010	3	2
UCEC	STAT3_pY705 →	-0.348	-2.449	.004	.019	3	1
UCEC	ATM →	-0.702	-2.584	<.001	.011	2	2
UCEC	Cyclin-B1 →	+0.576	+2.584	.027	.011	3	1
UCEC	PCNA →	+0.272	+2.584	.006	.011	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

eIF4E by GRK2 expression — UCEC

Explore this box plot interactively →