GRK2

Across TCGA cell cohorts, GRK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,547 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRK2-associated GO terms across cancer lineages are Viral genome replication, mRNA alternative polyadenylation, and CAAX-box protein processing. Each is linked with GRK2 in more than 17 cancer types. Because this analysis shows association rather than direction, both GRK2-to-partner and partner-to-GRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral genome replication grouped by GRK2-low versus GRK2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK2→partner) and Y-score (partner→GRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Viral genome replication →	+0.147	+1.346	.003	.003	2	18
BONE	mRNA alternative polyadenylation →	+0.098	+1.439	.001	<.001	3	14
OESOPHAGUS	CAAX-box protein processing →	+0.198	+1.408	.001	.005	2	14
BONE	Pre-mRNA catabolic process →	+0.213	+0.874	<.001	<.001	3	13
LARGE_INTESTINE	Copper ion export →	-0.158	-1.247	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	snoRNA guided rRNA pseudouridine synthesis →	-0.103	-0.992	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,547 associations by consensus.

Viral genome replication by GRK2 expression — URINARY_TRACT

Explore this box plot interactively →