GRK2

Across TCGA cell cohorts, GRK2 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRK2-associated genes across cancer lineages are SHOX, SLAMF1, and MAGEB4. Each is linked with GRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK2-to-partner and partner-to-GRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHOX grouped by GRK2-low versus GRK2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK2→partner) and Y-score (partner→GRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SHOX →	+0.284	+2.864	<.001	.009	3	2
LARGE_INTESTINE	SLAMF1 →	+0.049	+3.555	<.001	.003	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	CSN1S1 →	+0.042	+3.084	<.001	.002	3	1
LARGE_INTESTINE	KLHDC7B →	+0.457	+3.444	.008	.003	3	1
LARGE_INTESTINE	LMNTD1 →	+0.152	+2.817	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

SHOX by GRK2 expression — CNS

Explore this box plot interactively →