Across TCGA patient cohorts, GRK1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRK1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and Shc_pY317. Each is linked with GRK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK1-to-partner and partner-to-GRK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK1→partner) and Y-score (partner→GRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.360	-2.000	.047	.030	3	2
UCEC	PCNA →	+0.202	+1.906	.020	.016	3	2
UCEC	Shc_pY317 →	-0.159	-2.415	.009	.003	3	2
UCEC	ATM →	-0.663	-3.087	<.001	<.001	3	2
UCEC	c-Met_pY1235 →	+0.062	+1.906	.036	.016	3	2
UCEC	EGFR_pY1068 →	-0.235	-1.906	.020	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

GRK1 survival (RNA) · tumor vs normal (RNA) · all GRK1 data types