Across TCGA cell cohorts, GRK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,382 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible GRK1-associated GO terms across cancer lineages are G protein-coupled opsin signaling pathway, Positive regulation of monoatomic ion transmembrane transport, and Sodium ion transport. Each is linked with GRK1 in more than 13 cancer types. Because this analysis shows association rather than direction, both GRK1-to-partner and partner-to-GRK1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK1→partner) and Y-score (partner→GRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	G protein-coupled opsin signaling pathway →	+0.292	+0.381	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of monoatomic ion transmembrane transport →	-0.082	-0.034	.001	.004	3	6
SOFT_TISSUE	Sodium ion transport →	-0.038	-0.124	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Positive regulation of potassium ion transmembrane transport →	-0.128	-0.028	.004	<.001	3	5
LUNG_SCLC	Positive regulation of neurotransmitter uptake →	-0.202	-0.896	.001	<.001	3	5
BONE	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.186	+0.146	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,382 associations by consensus.

Exploration

GRK1 survival (RNA) · tumor vs normal (RNA) · all GRK1 data types