GRIPAP1

Across TCGA cell cohorts, GRIPAP1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIPAP1-associated genes across cancer lineages are HHLA1, SLC6A1, and LRRC72. Each is linked with GRIPAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIPAP1-to-partner and partner-to-GRIPAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by GRIPAP1-low versus GRIPAP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIPAP1→partner) and Y-score (partner→GRIPAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.006	+4.551	.002	.004	3	1
BLOOD_Leukemia	SLC6A1 →	+0.061	+4.874	<.001	.002	3	1
BLOOD_Leukemia	LRRC72 →	+0.029	+4.874	<.001	.002	3	1
LARGE_INTESTINE	GALR3 →	+0.139	+3.602	<.001	.005	3	1
LARGE_INTESTINE	MCHR2 →	+0.017	+3.099	<.001	.002	3	1
LARGE_INTESTINE	RBMXL2 →	+0.060	+2.817	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

HHLA1 by GRIPAP1 expression — BLOOD_Leukemia

Explore this box plot interactively →