GRIP2

Across TCGA patient cohorts, GRIP2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIP2-associated genes across cancer lineages are INPP4B, PDK1_pS241, and PKC-b-II_pS660. Each is linked with GRIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIP2-to-partner and partner-to-GRIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GRIP2-low versus GRIP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIP2→partner) and Y-score (partner→GRIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.391	-3.321	.009	.009	3	2
COAD	PDK1_pS241 →	-0.161	-1.991	.018	.031	3	2
COAD	PKC-b-II_pS660 →	-0.381	-3.169	.007	.017	3	2
UCEC	4E-BP1 →	+0.261	+3.807	.001	<.001	3	2
COAD	Cyclin-E1 →	+0.332	+3.169	.001	.017	3	2
UCEC	Lck →	+0.151	+1.064	.014	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

INPP4B by GRIP2 expression — COAD

Explore this box plot interactively →