GRINA

Across TCGA pan-cancer cohorts, GRINA Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GRINA data layer compared with 29 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GRINA Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRINA expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, ESCA, and LUSC are the cancer types where GRINA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.144	0.705	.004	18	view →
ESCA	DFS	Median	All	0.052	0.533	<.001	12	view →
LUSC	DFS	Median	All	0.185	0.758	.010	12	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
UCEC	DFS	Median	All	1.000	0.632	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GRINA–CESC (DFS)

Open the CESC breakdown →