GRINA

Across TCGA patient cohorts, GRINA mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRINA-associated genes across cancer lineages are Mesangial cells, Th2 cells, and CD4+ Tem. Each is linked with GRINA in more than 1 cancer types. Because this analysis shows association rather than direction, both GRINA-to-partner and partner-to-GRINA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mesangial cells grouped by GRINA-low versus GRINA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRINA→partner) and Y-score (partner→GRINA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Mesangial cells →	-0.039	-2.983	.023	.036	3	1
UCEC	Th2 cells →	+0.175	+2.000	.031	.032	3	1
PAAD	CD4+ Tem →	+0.057	+6.442	<.001	.022	3	1
UCEC	Endothelial cells →	-0.043	-2.657	.011	.006	1	1
UCEC	lymphatic Endothelial cells →	-0.027	-3.753	.010	<.001	1	1
UCEC	mv Endothelial cells →	-0.029	-3.796	.005	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Mesangial cells by GRINA expression — UCEC

Explore this box plot interactively →