GRINA

Across TCGA cell cohorts, GRINA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,550 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRINA-associated GO terms across cancer lineages are Positive regulation of autophagy, Negative regulation of autophagy, and Regulation of pattern recognition receptor signaling pathway. Each is linked with GRINA in more than 12 cancer types. Because this analysis shows association rather than direction, both GRINA-to-partner and partner-to-GRINA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of autophagy grouped by GRINA-low versus GRINA-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRINA→partner) and Y-score (partner→GRINA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.055	+1.004	<.001	<.001	3	13
STOMACH	Negative regulation of autophagy →	+0.083	+0.906	.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.059	+1.149	<.001	<.001	3	12
SKIN	Multi-pass transmembrane protein insertion into ER membrane →	+0.151	+1.151	<.001	<.001	3	11
CNS	Viral process →	+0.079	+0.849	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular transport →	+0.060	+1.092	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,550 associations by consensus.

Positive regulation of autophagy by GRINA expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →