GRINA

Across TCGA cell cohorts, GRINA mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRINA-associated genes across cancer lineages are TAFA1, CENPVL3, and OOSP4A. Each is linked with GRINA in more than 1 cancer types. Because this analysis shows association rather than direction, both GRINA-to-partner and partner-to-GRINA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by GRINA-low versus GRINA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRINA→partner) and Y-score (partner→GRINA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	CENPVL3 →	+0.230	+3.242	<.001	.003	3	1
LARGE_INTESTINE	OOSP4A →	+0.065	+3.115	.006	.004	3	1
SKIN	DAZ2 →	+0.505	+3.707	<.001	.009	3	1
BLOOD_Leukemia	IRS4 →	+0.043	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR51T1 →	+0.081	+5.507	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

TAFA1 by GRINA expression — LARGE_INTESTINE

Explore this box plot interactively →