GRIN3B

Across TCGA pan-cancer cohorts, GRIN3B Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GRIN3B data layer compared with 24 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher GRIN3B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRIN3B expression acts as an unfavorable survival marker.

BRCA, CESC, and LUSC are the cancer types where GRIN3B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.210	0.903	<.001	36	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
LUSC	DFS	Median	II,III,IV	0.213	0.724	<.001	12	view →
HNSC	DFS	Median	All	0.098	0.710	<.001	12	view →
SCLC	OS	Median	All	0.219	0.706	.011	6	view →
LUAD	OS	Median	II,III,IV	0.090	0.677	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GRIN3B–BRCA (DFS)

Open the BRCA breakdown →