GRIN3B

Across TCGA patient cohorts, GRIN3B mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. COAD shows the largest number of these associations.

The most reproducible GRIN3B-associated genes across cancer lineages are DC, Macrophages, and CD8+ Tem. Each is linked with GRIN3B in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIN3B-to-partner and partner-to-GRIN3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DC grouped by GRIN3B-low versus GRIN3B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN3B→partner) and Y-score (partner→GRIN3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DC →	+0.033	+2.871	<.001	.008	3	2
COAD	Macrophages →	+0.020	+2.440	.010	.019	3	2
UCEC	CD8+ Tem →	+0.003	+4.481	<.001	.047	3	2
LUSC	Th1 cells →	+0.145	+2.819	.004	.036	2	2
COAD	Astrocytes →	+0.040	+2.107	.011	.044	3	1
COAD	Preadipocytes →	+0.055	+3.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DC by GRIN3B expression — COAD

Explore this box plot interactively →