GRIN3B

Across TCGA cell cohorts, GRIN3B mutation is significantly associated with the RNA expression of many other genes, with 349 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIN3B-associated genes across cancer lineages are IP6K3, FBXO36, and TNK1. Each is linked with GRIN3B in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIN3B-to-partner and partner-to-GRIN3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IP6K3 grouped by GRIN3B-low versus GRIN3B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN3B→partner) and Y-score (partner→GRIN3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IP6K3 →	+0.106	+3.592	<.001	.006	3	2
LARGE_INTESTINE	FBXO36 →	+0.638	+2.628	<.001	.002	3	2
LARGE_INTESTINE	TNK1 →	+0.709	+2.523	.003	.003	3	2
OESOPHAGUS	LILRA1 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	GAGE12H →	+0.053	+4.906	<.001	.006	3	1
BLOOD_Leukemia	GML →	+0.058	+3.304	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 349 associations by consensus.

IP6K3 by GRIN3B expression — BLOOD_Lymphoma

Explore this box plot interactively →