Across TCGA pan-cancer cohorts, GRIN3A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated GRIN3A data layer compared with 20 for mass-spec protein.
The strongest signal is observed in thymoma (THYM), where higher GRIN3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GRIN3A expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.
THYM, COAD, and ACC are the cancer types where GRIN3A Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.