GRIN1

Across TCGA patient cohorts, GRIN1 mutation is significantly associated with the RNA expression of many other genes, with 1,886 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIN1-associated genes across cancer lineages are SDHB, ATP6V1D, and SAAL1. Each is linked with GRIN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIN1-to-partner and partner-to-GRIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDHB grouped by GRIN1-low versus GRIN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN1→partner) and Y-score (partner→GRIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SDHB →	+0.501	+3.220	.006	.009	3	3
UCEC	ATP6V1D →	+0.347	+2.321	.006	.005	3	3
UCEC	SAAL1 →	+0.372	+3.332	.009	.005	3	3
UCEC	LSM3 →	+0.406	+2.032	.008	.005	3	3
COAD	RNU6-128P →	+0.356	+3.781	.001	.002	3	3
COAD	SUMO2P7 →	+0.205	+3.246	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,886 associations by consensus.

SDHB by GRIN1 expression — SKCM

Explore this box plot interactively →