GRIN1

Across TCGA patient cohorts, GRIN1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIN1-associated genes across cancer lineages are NF-kB-p65_pS536, PDCD4, and ATM. Each is linked with GRIN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRIN1-to-partner and partner-to-GRIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by GRIN1-low versus GRIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN1→partner) and Y-score (partner→GRIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF-kB-p65_pS536 →	-0.339	-2.999	.047	.035	3	4
UCEC	PDCD4 →	-0.462	-2.105	.008	.017	3	3
UCEC	ATM →	-0.535	-2.169	.001	.003	3	3
UCEC	DJ-1 →	+0.160	+1.415	.010	.046	3	3
LUAD	cIAP →	+0.155	+2.819	.014	.035	3	2
UCEC	EGFR →	-0.172	-1.415	.004	.046	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

NF-kB-p65_pS536 by GRIN1 expression — UCEC

Explore this box plot interactively →