GRIN1

Across TCGA cell cohorts, GRIN1 mutation is significantly associated with the RNA expression of many other genes, with 421 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIN1-associated genes across cancer lineages are LYG1, SAMD8, and NAE1. Each is linked with GRIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIN1-to-partner and partner-to-GRIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by GRIN1-low versus GRIN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN1→partner) and Y-score (partner→GRIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LYG1 →	+0.673	+3.470	<.001	.002	3	2
BLOOD_Leukemia	SAMD8 →	+0.626	+3.351	.002	.003	3	2
LARGE_INTESTINE	NAE1 →	+0.886	+3.299	<.001	.004	3	2
LARGE_INTESTINE	SAAL1 →	+0.669	+3.064	.001	.009	3	2
BLOOD_Leukemia	CDK1 →	+0.637	+3.351	.005	.003	3	2
LARGE_INTESTINE	BTG3 →	+0.848	+3.131	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 421 associations by consensus.

LYG1 by GRIN1 expression — BLOOD_Leukemia

Explore this box plot interactively →