GRIK5

Across TCGA cell cohorts, GRIK5 mutation is significantly associated with the RNA expression of many other genes, with 385 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIK5-associated genes across cancer lineages are ADGRE3, OR4X2, and KRTAP17-1. Each is linked with GRIK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIK5-to-partner and partner-to-GRIK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRE3 grouped by GRIK5-low versus GRIK5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK5→partner) and Y-score (partner→GRIK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADGRE3 →	+0.005	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR4X2 →	+0.013	+4.369	.006	.008	3	1
SOFT_TISSUE	KRTAP17-1 →	+0.011	+4.369	<.001	.008	3	1
SOFT_TISSUE	SLC22A24 →	+0.005	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR6C3 →	+0.554	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR6C1 →	+1.075	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 385 associations by consensus.

ADGRE3 by GRIK5 expression — SOFT_TISSUE

Explore this box plot interactively →