GRIK4

Across TCGA pan-cancer cohorts, GRIK4 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated GRIK4 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher GRIK4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GRIK4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, LUSC, and SCLC are the cancer types where GRIK4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.250	0.692	.009	18	view →
LUSC	DFS	Median	III,IV	0.186	0.669	<.001	15	view →
SCLC	OS	Median	III,IV	0.082	0.630	.001	12	view →
HNSC	OS	Median	II,III,IV	0.174	0.671	.031	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
STAD	OS	Median	III,IV	0.196	0.632	.026	6	view →
ESCA	OS	Median	All	0.211	0.876	.028	6	view →
PRAD	DFS	Median	All	0.085	0.774	.001	6	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	6	view →
UCEC	DFS	Median	All	0.929	0.619	.026	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

GRIK4–OV (OS)

Open the OV breakdown →