GRIK1

Across TCGA patient cohorts, GRIK1 mutation is significantly associated with the RNA expression of many other genes, with 4,247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIK1-associated genes across cancer lineages are MIR4797, SAPCD2, and H2AX. Each is linked with GRIK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRIK1-to-partner and partner-to-GRIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4797 grouped by GRIK1-low versus GRIK1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK1→partner) and Y-score (partner→GRIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4797 →	+0.819	+5.054	<.001	.001	3	5
UCEC	SAPCD2 →	+0.473	+2.148	.001	<.001	3	4
LUAD	H2AX →	+0.733	+3.593	<.001	.001	2	5
BRCA	BLOC1S3 →	+0.387	+3.392	.004	.005	3	4
LUAD	NIPAL2 →	-0.754	-3.538	<.001	.002	3	4
LUAD	PTBP1 →	+0.398	+3.483	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,247 associations by consensus.

MIR4797 by GRIK1 expression — READ

Explore this box plot interactively →