GRIK1

Across TCGA patient cohorts, GRIK1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIK1-associated genes across cancer lineages are PDCD4, ATM, and 4E-BP1. Each is linked with GRIK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRIK1-to-partner and partner-to-GRIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by GRIK1-low versus GRIK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK1→partner) and Y-score (partner→GRIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.384	-1.222	.004	.011	3	3
UCEC	ATM →	-0.607	-2.000	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.262	+3.906	<.001	<.001	3	3
LUSC	Cyclin-B1 →	+0.508	+2.816	.040	.036	1	4
LUAD	Heregulin →	-0.122	-3.000	.046	.035	3	2
LUAD	MSH6 →	+0.353	+2.824	.007	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PDCD4 by GRIK1 expression — UCEC

Explore this box plot interactively →