GRIK1

Across TCGA cell cohorts, GRIK1 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIK1-associated genes across cancer lineages are OR11H2, DEFA6, and TFAP2D. Each is linked with GRIK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIK1-to-partner and partner-to-GRIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H2 grouped by GRIK1-low versus GRIK1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK1→partner) and Y-score (partner→GRIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR11H2 →	+0.041	+3.280	<.001	.002	3	2
BLOOD_Leukemia	DEFA6 →	+0.305	+3.691	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	2
OVARY	CYP2C9 →	+1.052	+3.478	.002	.004	3	1
OVARY	DRD3 →	+0.012	+3.821	<.001	<.001	3	1
OVARY	CYP2C19 →	+0.350	+3.824	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

OR11H2 by GRIK1 expression — OVARY

Explore this box plot interactively →