Across TCGA patient cohorts, GRID2IP mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRID2IP-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and eEF2. Each is linked with GRID2IP in more than 1 cancer types. Because this analysis shows association rather than direction, both GRID2IP-to-partner and partner-to-GRID2IP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRID2IP→partner) and Y-score (partner→GRID2IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.744	+3.107	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.085	-2.432	.013	.018	3	1
UCEC	eEF2 →	+0.335	+2.700	.006	.005	3	1
UCEC	EGFR_pY1068 →	-0.286	-2.137	<.001	.001	3	1
UCEC	ERK2 →	+0.275	+2.523	<.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.092	-1.247	.030	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

GRID2IP survival (RNA) · tumor vs normal (RNA) · all GRID2IP data types