GRID2

Across TCGA pan-cancer cohorts, GRID2 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated GRID2 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GRID2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GRID2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, UVM, and DLBC are the cancer types where GRID2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.965	0.822	.002	34	view →
UVM	OS	Median	All	0.104	0.858	<.001	33	view →
DLBC	OS	Median	III,IV	0.172	0.907	<.001	12	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
BLCA	DFS	Median	III,IV	0.216	0.554	.001	9	view →
LIHC	DFS	Median	All	0.038	0.556	<.001	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SARC	DFS	Median	All	0.121	0.611	.048	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	DFS	Median	III,IV	0.778	0.545	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

GRID2–UCEC (DFS)

Open the UCEC breakdown →