GRID1

Across TCGA patient cohorts, GRID1 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GRID1-associated genes across cancer lineages are GSK3-a-b, TFRC, and Cyclin-B1. Each is linked with GRID1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GRID1-to-partner and partner-to-GRID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK3-a-b grouped by GRID1-low versus GRID1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRID1→partner) and Y-score (partner→GRID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GSK3-a-b →	+0.229	+2.824	.006	.034	3	4
LUAD	TFRC →	+0.688	+3.584	<.001	.002	3	3
LUAD	Cyclin-B1 →	+0.695	+2.247	<.001	.001	3	3
LUSC	HSP70 →	-0.501	-1.874	.010	.049	3	3
HNSC	NF2 →	+0.335	+2.834	.003	.031	3	3
UCEC	eIF4E →	+0.148	+1.295	.016	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

GSK3-a-b by GRID1 expression — BLCA

Explore this box plot interactively →