GRID1

Across TCGA cell cohorts, GRID1 mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRID1-associated genes across cancer lineages are SPATA19, CCDC196, and SNX16. Each is linked with GRID1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRID1-to-partner and partner-to-GRID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA19 grouped by GRID1-low versus GRID1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRID1→partner) and Y-score (partner→GRID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SPATA19 →	+0.033	+4.807	<.001	.006	3	2
LUNG_NSCLC_LUAD	CCDC196 →	+0.042	+3.706	<.001	.005	3	2
LARGE_INTESTINE	SNX16 →	+0.442	+2.743	.006	.001	3	2
LARGE_INTESTINE	ZNF330 →	+0.516	+3.652	<.001	<.001	3	2
LARGE_INTESTINE	DNAAF2 →	+0.343	+2.043	.008	.008	3	2
PANCREAS	CYP11B1 →	+0.013	+3.201	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

SPATA19 by GRID1 expression — BLOOD_Myeloma

Explore this box plot interactively →