GRIA3

Across TCGA patient cohorts, GRIA3 mutation is significantly associated with the RNA expression of many other genes, with 5,456 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIA3-associated genes across cancer lineages are FBXO7, FXYD6P2, and ACO2. Each is linked with GRIA3 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRIA3-to-partner and partner-to-GRIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO7 grouped by GRIA3-low versus GRIA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA3→partner) and Y-score (partner→GRIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO7 →	+0.339	+1.406	<.001	<.001	3	5
CESC	FXYD6P2 →	+0.084	+2.273	.002	.008	3	4
UCEC	ACO2 →	+0.561	+1.529	<.001	<.001	3	4
UCEC	CEP76 →	+0.238	+1.480	.004	.001	3	4
UCEC	SLC35B1 →	+0.346	+1.518	<.001	<.001	3	4
COAD	ARMC7 →	+0.535	+3.529	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,456 associations by consensus.

FBXO7 by GRIA3 expression — UCEC

Explore this box plot interactively →