GRIA2

Across TCGA patient cohorts, GRIA2 mutation is significantly associated with the RNA expression of many other genes, with 6,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIA2-associated genes across cancer lineages are PSMC3IP, L2HGDH, and EMC9. Each is linked with GRIA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both GRIA2-to-partner and partner-to-GRIA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by GRIA2-low versus GRIA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA2→partner) and Y-score (partner→GRIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.784	+2.436	<.001	<.001	3	5
UCEC	L2HGDH →	+0.442	+1.558	<.001	<.001	3	5
STAD	EMC9 →	+0.394	+3.234	.005	.008	3	5
UCEC	ADNP2 →	+0.659	+2.617	<.001	<.001	3	5
UCEC	CEP55 →	+0.558	+1.857	<.001	<.001	3	5
UCEC	POLE2 →	+0.460	+2.137	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,739 associations by consensus.

PSMC3IP by GRIA2 expression — UCEC

Explore this box plot interactively →